ICU Medical, which now owns Smiths Medical, hosts the current Medfusion 4000 Operator’s Manual for software V1.6, and you can download the earlier V1.1 manual, the Quick Reference Card and the original product brochure below. Always match the manual to the software version shown on your pump’s start-up screen. The Medfusion 4000 accepts 1 to 60 mL syringes, delivers 0.01 to 1130 mL/hr with ±2% nominal accuracy, runs on a rechargeable lithium-ion battery, and connects to PharmGuard Server over wired Ethernet or 802.11b/g wireless.
Whether you are training new staff, checking an alarm at the bedside or setting up a biomed PM program, the right Medfusion 4000 document saves time. This guide collects the documents we host, explains which one you need, and pulls out the specifications and reference details people ask us about most.
Download the Medfusion 4000 Manuals
Operator’s Manual, Software V1.6 (current)
The current operator’s manual from Smiths Medical (now part of ICU Medical), hosted by ICU Medical, for pumps running V1.6 software. Use this edition for pumps on v1.6.x, including v1.6.5.
View on icumed.comOperator’s Manual, Software V1.1
The full 154-page operator’s manual for pumps running software version V1.1: PharmGuard dose limits, programming, bolus and loading doses, alarms and remedies, battery, MRI information, cleaning, maintenance and specifications.
Download PDFQuick Reference Card
A 12-page bedside card with the pump’s controls and features, syringe loading and the main programming steps.
Download PDFProduct Brochure
The original two-page brochure covering the pump’s headline specifications, wireless connectivity and the PharmGuard Toolbox and PharmGuard Server software.
Download PDFThese documents are provided for reference. They are the original manufacturer’s documents and are not maintained or updated by IPR Medical. For more manuals, browse our Manuals & Documentation Library.
Which Medfusion 4000 Manual Do You Need?
The Operator’s Manual itself says to always verify that the software version shown on the pump’s start-up screen matches the version on the manual’s front page. Here is how the documents fit together:
| Document | Who uses it | Notes |
|---|---|---|
| Operator’s Manual (by software version) | Clinicians, educators, biomed | ICU Medical hosts the current V1.6 edition. The V1.1 edition we host applies to pumps on V1.1 software. For pumps on other versions (for example v1.5.x), request the matching edition from ICU Medical. |
| Quick Reference Card | Clinicians at the bedside | Summary only; not a substitute for the full manual. |
| Technical Service Manual (the operator’s manual cites catalog number 67-2452-51; the current 2023 edition is P/N 10014940-009) | Trained biomedical technicians | Covers functional description, theory of operation, calibration, diagnosis and testing, and service parts. The 2023 edition includes the updated force sensor check. Available from ICU Medical technical service; not hosted here. |
| PharmGuard Toolbox 2 User’s Manual and Network Settings manual | Pharmacy, IT and biomed | Building configurations and drug libraries, and setting up wired or wireless communication. |
Not sure which software your pump runs, or whether an update applies? Our Medfusion 4000 recall and software versions guide explains how to check and what the FDA-tracked corrections mean.
What’s Inside the Operator’s Manual
- Important safety information: warnings, cautions and symbols, including the MRI and ECMO warnings.
- PharmGuard dose protection: soft and hard limits, profiles, library categories and Quick Libraries.
- Programming: continuous, mass, body-weight and intermittent modes, volume over time, bolus and loading doses, KVO, standby, delayed start and volume limits.
- FlowSentry occlusion detection: time to occlusion, the occlusion trend graph and post-occlusion bolus reduction.
- Alarms and remedies: the full alarm table, including battery, system failure and system advisory messages.
- Battery, pole clamp, cleaning and maintenance: how to charge and store the pump, mount it safely, clean it and keep it on a yearly service schedule.
- Technical specifications: accuracy, occlusion settings, flow and bolus ranges, power, environment and standards.
Key Medfusion 4000 Specifications
From the Operator’s Manuals for software V1.6 and V1.1 and the original brochure. Where the two editions differ, both are shown; confirm against the manual for your version.
| Specification | Medfusion 4000 |
|---|---|
| Syringe sizes | 1 to 60 mL |
| Infusion rate range | 0.01 to 1130 mL/hr, in 0.01 or 0.1 mL/hr increments depending on syringe size and rate |
| Delivery accuracy | Nominal ±2% (plus syringe accuracy) |
| Delivery modes | mL/hr, dose per min, hr or day, dose per kg or m² per time, mL/kg per time, volume over time, and intermittent modes |
| Occlusion settings | Very Low 4 psi, Low 8 psi, Normal 12 psi, High 16 psi; fixed at Very High (50 psi) for 1 mL syringes |
| Drug libraries | Up to 8 categories of 36 drug programs per profile (288 entries), plus one Quick Library per profile |
| Battery life | V1.6 manual: 400 charge cycles or 2 years, whichever comes first. V1.1 manual: 400 charge cycles minimum. |
| Battery run time | V1.6 manual: at least 7 hours at 25 °C, 5 mL/hr with a 60 mL syringe, while communicating. V1.1 manual: about 10 hours typical at 5.0 mL/hr with a 60 mL syringe. |
| AC power | 100–240 VAC, 50/60 Hz, 42 VA; Safety Class II, Type CF |
| Size and weight | 10.5 × 6.2 × 5.7 in (27 × 16 × 14.5 cm); about 4.54 lb (2.04 kg) |
| Fluid protection | IPX3 (spray resistant) |
| Connectivity | Ethernet and 802.11b/g wireless to PharmGuard Server; configurations from PharmGuard Toolbox 2 |
| MRI | MR Conditional when secured to a non-moveable object where the magnetic fringe field does not exceed 150 gauss (V1.6); the V1.1 manual also specified shielded 1.5 Tesla magnets |
| Operating conditions | 5 to 40 °C (40 to 104 °F); 20 to 95% relative humidity, non-condensing |
Medfusion Standard Syringes
The pump only accepts syringe models defined in its configuration. The Operator’s Manual lists these Medfusion Standard Syringes, with more available through the PharmGuard Supported Syringes (PSS) Series 2:
- BD: 1, 3, 5, 10, 20, 30 and 60 mL Luer-Lok, plus a 1 mL slip tip (tuberculin) syringe
- Monoject (Covidien): 3, 6, 12, 20, 35 and 60 mL Luer lock, plus a 1 mL slip tip (tuberculin) syringe. Cardinal Health-branded Monoject syringes are not qualified for this pump.
- Terumo: 3, 5, 10, 20, 30 and 60 mL Luer lock, plus a 1 mL slip tip (tuberculin) syringe
- B. Braun Omnifix: 5, 10, 20 and 50 mL Luer lock
- B. Braun Perfusor: 20 and 50 mL Luer lock
Always confirm that the brand and size the pump displays match the syringe you loaded. Important: in February 2024, Smiths Medical (now part of ICU Medical) told users not to use Cardinal Health-branded Monoject syringes on Medfusion 3500 and 4000 pumps; see our recall and software versions guide.
Quick Reference from the Manual
| Topic | What the manual says |
|---|---|
| Software version | Shown on the start-up screen; verify it matches your manual. |
| Charging after full depletion | Plug in, restart, and leave on AC for at least 8 hours to fully recharge. |
| Storage | If the pump will not charge, or has been stored more than ten months without charging (V1.1 manual: two months), contact service. |
| Preventive maintenance | Test at least yearly and whenever the pump is dropped or damaged; check the occlusion and other sensors yearly. |
| Maintenance reminder | System Advisory: Maintenance is Recommended repeats at every power-up until a biomed technician resets it. |
| System failures | Turn the pump off and on once; if the failure persists, remove the pump from service. |
| Cleaning | V1.6 manual: 70% isopropyl alcohol, household bleach (6% diluted 1:6, or 1.0%), Sani-Cloth Bleach, or mild detergent and water, applied with a soft cloth. Never use the prohibited solvents (including accelerated hydrogen peroxide), oil sprays, immersion or autoclaving. |
| Mounting | Use the pump horizontally on a stable pole with the pole clamp fully tightened. |
For what these messages usually mean in practice, see our Medfusion 4000 common problems and repair guide.
Service and Repair
IPR Medical evaluates, repairs, calibrates and tests Medfusion 4000 pumps in-house at our ISO 9001:2015-certified facility in Tustin, California. U.S. customers get a free inbound shipping label and a free evaluation, and nothing is charged until you approve the estimate. We also update pump software as part of service. Learn more on our Medfusion repair service page, or shop recertified (refurbished) Medfusion 4000 syringe pumps with a 1-year warranty.
Medfusion 4000 Manual FAQ
Where can I download the Medfusion 4000 operator’s manual?
ICU Medical publishes the current V1.6 Operator’s Manual on its website, linked above. You can also download the earlier V1.1 manual, the Quick Reference Card and the product brochure from this page.
How do I find the software version on a Medfusion 4000?
The software version is displayed on the start-up screen when you turn the pump on. The manual instructs users to confirm that it matches the version on the manual’s front page.
What syringe sizes does the Medfusion 4000 accept?
The Medfusion 4000 accepts 1 to 60 mL syringes. Only syringe models defined in the pump’s configuration can be used, including the Medfusion Standard Syringes and PharmGuard Supported Syringes.
What is the flow rate range of the Medfusion 4000?
0.01 to 1130 mL/hr, with nominal ±2% delivery accuracy plus syringe accuracy.
What is the battery run time of a Medfusion 4000?
The current V1.6 manual specifies at least 7 hours at 5 mL/hr with a 60 mL syringe while the pump is communicating on the network; the earlier V1.1 manual listed about 10 hours typical. The battery is rated for 400 charge cycles or two years, whichever comes first.
Is the Medfusion 4000 MR Conditional?
Yes. The current V1.6 Operator’s Manual labels it MR Conditional when it is secured to a non-moveable object where the magnetic fringe field does not exceed 150 gauss (the older V1.1 manual also specified shielded 1.5 Tesla magnets). Follow your pump’s labeling and your facility’s MRI safety policy.
Where can I get the Medfusion 4000 Technical Service Manual?
The Medfusion Model 4000 Series Technical Service Manual (cited in the operator’s manual as catalog number 67-2452-51; the current 2023 edition is P/N 10014940-009) is available from ICU Medical technical service for trained biomedical technicians. If you need a pump serviced instead, request a free shipping label and we will evaluate it.
Does the Medfusion 4000 need annual maintenance?
Yes. The manual calls for testing at least yearly, including the occlusion and other sensors, and whenever the pump has been dropped or damaged.
Need Help With a Medfusion 4000?
Questions about a manual, an alarm or a repair? Our team can help, Monday through Friday, 7:00 AM to 4:30 PM Pacific.
Medfusion, PharmGuard and FlowSentry are trademarks of their respective owners and are used here only to identify the original manufacturer’s equipment and documentation. IPR Medical is an ISO 9001:2015-certified independent service organization and is not sponsored by, affiliated with, or endorsed by the original equipment manufacturer. Manuals and brochures are the manufacturer’s documents, provided for reference; specifications are taken from the V1.6 and V1.1 Operator’s Manuals and may differ for other software versions. All other product names and trademarks are the property of their respective owners and are used only to identify those owners’ products; IPR Medical is not sponsored by, affiliated with, or endorsed by any of these trademark owners.